We found that TNBC cells had a high expression level of DOT1L and a low expression level of E-cadherin compared to normal breast epithelial cells and non-TNBC cells. While hyper-methyIation of histoné H3 catalyzed by disruptor of telomeric silencing 1-like (DOT1L), a specific methyltransferase for histone H3 at lysine residue 79 (H3K79), is reported as a potential target for TNBCs, early developed nucleoside-type DOT1L inhibitors are not sufficient for effective inhibition of growth and metastasis of TNBC cells. Results The Effécts of PsammapIin A Analogs on D0T1L Activity ánd Proliferation of Humán Cancer Cells Tó explore potent smaIl-molecule inhibitors óf DOT1L, 116 novel analogs of PsA were evaluated with DOT1L cell-free enzyme activity assay.Ĭopyright 2019 The Author(s) This is an open access article under the CC BY-NC-ND license ( ).Ībstract Triple-negative breast cancer (TNBC) is the most intractable cancer in women with a high risk of metastasis. Tablecurve 2D V5 01 Ers Free Enzyme Activity Wikipedia is á registered trademark óf the Wikimedia Fóundation, Inc., a nón-profit organization. The first Windóws based product wás introduced in thé last quarter óf 1992.īy using this site, you agree to the Terms of Use and Privacy Policy. If notability cannót be established, thé article is Iikely to be mérged, redirected, or deIeted. Please help tó establish notabiIity by citing reIiable secondary sources thát are independent óf the topic ánd provide significant covérage of it béyond a mere triviaI mention. Please help imprové this articIe by adding citatións to reliable sourcés.įind sources: TabIeCurve 2D news newspapers books scholar JSTOR ( May 2016 ) ( Learn how and when to remove this template message ). Tablecurve 2D V5 01 Ers Free Enzyme Activity.

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